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The frequency of Tay-Sachs disease among Ashkenazi Jews is estimated to be 1 in 3,600 births, significantly higher than the general population. Seizures can manifest in a variety of ways, from brief, subtle twitches to prolonged, convulsive episodes. Some seizures may involve only a part of the body, while others may affect the entire body. The type and severity of seizures can vary widely from person to person and can change over time as the disease progresses.